New insights on mitochondrial heteroplasmy observed in ovarian diseases

Autor: Yong Zhou, Yang Jin, Tianyu Wu, Yinfeng Wang, Yuanhang Dong, Pei Chen, Changchang Hu, Ningping Pan, Chaoshuang Ye, Li Shen, Mengyan Lin, Tao Fang, Ruijin Wu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Advanced Research, Vol 65, Iss , Pp 211-226 (2024)
Druh dokumentu: article
ISSN: 2090-1232
DOI: 10.1016/j.jare.2023.11.033
Popis: Background: The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be attributed to the absence of histone protection and complete repair mechanisms. Mitochondrial heteroplasmy refers to the coexistence of wild-type and mutant mtDNA. Most healthy individuals carry a low point mutation load (
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