Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease

Autor: Man Li, Lei Duan, Yu-Lun Cai, Hui-Ying Li, Ben-Chuan Hao, Jian-Qiao Chen, Hong-Bin Liu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-12 (2020)
Druh dokumentu: article
ISSN: 1475-2840
DOI: 10.1186/s12933-020-01092-7
Popis: Abstract Background Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the present cohort study is to investigate the prognostic value of GDF-15 in patients with coronary artery disease (CAD) during long-term follow up. Methods A total of 3641 consecutive patients with CAD were prospectively enrolled into the study and followed up for major adverse cardiovascular events (MACEs) and all-cause death up to 5.3–7.6 years. Plasma GDF-15 was measured and clinical data and long-term events were registered. The patients were subsequently divided into three groups by the levels of GDF-15 and the prognostic value of GDF-15 level with MACEs and all-cause death was evaluated. Results After a median follow-up at 6.4 years later, 775 patients (event rate of 21%) had developed MACEs and 275 patients died (event rate of 7.55%). Kaplan–Meier analysis indicated that the patients with GDF-15 > 1800 ng/L were significantly associated with an increased risk of MACEs and all-cause death. Cox regression analysis indicated that GDF-15 > 1800 ng/L were independently associated with the composite of MACEs (HR 1.74; 95% CI 1.44–2.02; P
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