Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis
| Autor: | Supanat Worawichawong, Suchin Worawichawong, Piyanuch Radinahamed, Dittapol Muntham, Nuankanya Sathirapongsasuti, Arkom Nongnuch, Montira Assanatham, Chagriya Kitiyakara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Biomarker
Chronic kidney disease EGF Epidermal Growth Factor Fibrosis Glomerulonephritis Kidney NGAL Neutrophil gelatinase-associated lipocalin MCP-1 Monocyte chemoattractant protein-1 Tubulointerstitial Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 |
| Zdroj: | Kidney & Blood Pressure Research, Vol 41, Iss 6, Pp 997-1007 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1420-4096 1423-0143 79209505 |
| DOI: | 10.1159/000452595 |
| Popis: | Background/Aims: The degree of tubular atrophy and interstitial fibrosis (IFTA) is an important prognostic factor in glomerulonephritis. Imbalance between pro-inflammatory cytokines such as monocyte chemoattractant protein- 1 (MCP-1) and protective cytokines such as epidermal growth factor (EGF) likely determine IFTA severity. In separate studies, elevated MCP-1 and decreased EGF have been shown to be associated with IFTA severity. In this study, we aim to evaluate the predictive value of urinary EGF/MCP-1 ratio compared to each biomarker individually for moderate to severe IFTA in primary glomerulonephritis (GN). Methods: Urine samples were collected at biopsy from primary GN (IgA nephropathy, focal and segmental glomerulosclerosis, minimal change disease, membranous nephropathy). MCP-1 and EGF were analyzed by enzyme-linked immunosorbent assay. Results: EGF, MCP-1 and EGF/MCP-1 ratio from primary GN, all correlated with IFTA (n=58). By univariate analysis, glomerular filtration rate, EGF, and EGF/MCP-1 ratio were associated with IFTA. By multivariate analysis, only EGF/MCP-1 ratio was independently associated with IFTA. EGF/MCP-1 ratio had a sensitivity of 88% and specificity of 74 % for IFTA. EGF/MCP-1 had good discrimination for IFTA (AUC=0.85), but the improvement over EGF alone was not significant. Conclusion: EGF/MCP-1 ratio is independently associated IFTA severity in primary glomerulonephritis, but the ability of EGF/MCP-1 ratio to discriminate moderate to severe IFTA may not be much better than EGF alone. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|