| Autor: |
Nazanin Mohammadzadeh, Weston Roda, William G. Branton, Julien Clain, Henintsoa Rabezanahary, Ouafa Zghidi-Abouzid, Benjamin B. Gelman, Jonathan B. Angel, Eric A. Cohen, M. John Gill, Michael Li, Jérome Estaquier, Christopher Power |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
mBio, Vol 12, Iss 6 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2150-7511 |
| DOI: |
10.1128/mBio.02784-21 |
| Popis: |
ABSTRACT HIV infection persists in different tissue reservoirs among people with HIV (PWH) despite effective antiretroviral therapy (ART). In the brain, lentiviruses replicate principally in microglia and trafficking macrophages. The impact of ART on this viral reservoir is unknown. We investigated the activity of contemporary ART in various models of lentivirus brain infection. HIV-1 RNA and total and integrated DNA were detected in cerebral cortex from all PWH (n = 15), regardless of ART duration or concurrent plasma viral quantity and, interestingly, integrated proviral DNA levels in brain were significantly higher in the aviremic ART-treated group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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