Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection

Autor: Serena Vita, Paola Zuccalà, Stefano Savinelli, Claudia Mascia, Raffaella Rossi, Francesco Schiavone, Raffaella Marocco, Tiziana Tieghi, Marco Iannetta, Parni Nijhawan, Maria Antonella Zingaropoli, Gabriella d’Ettore, Vincenzo Vullo, Claudio Maria Mastroianni, Miriam Lichtner
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Immunology Research, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2314-8861
2314-7156
DOI: 10.1155/2020/2781350
Popis: Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.
Databáze: Directory of Open Access Journals
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