Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

Autor: Feng Li, Wenting Yu, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-21442-7
Popis: Controlled delivery of siRNA is important for potential clinical applications. Here, the authors report on the use of cascade hybridization of DNA hairpins with ATP aptamers in DNA crosslinked polymer nanoparticles for triggered release of siRNA and demonstrate anticancer applications.
Databáze: Directory of Open Access Journals