Gingival enlargement as an early diagnostic indicator in therapy-related acute myeloid leukemia: A rare case report and review of literature

Autor: Triveni M Gowda, Raison Thomas, Shruthi M Shanmukhappa, Garima Agarwal, Dhoom S Mehta
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Journal of Indian Society of Periodontology, Vol 17, Iss 2, Pp 248-252 (2013)
Druh dokumentu: article
ISSN: 0972-124X
DOI: 10.4103/0972-124X.113090
Popis: Treatment for Hodgkin′s lymphoma (HL) has resulted in excellent survival rates but is associated with increased risks of secondary therapy-related acute myeloid leukemia (t-AML). Gingival enlargement associated with bleeding and ulceration is the most common rapidly appearing oral manifestations of leukemic involvement. An 8 months pregnant patient reported with generalized gingival enlargement, with localized cyanotic and necrotic papillary areas. Co-relating the hematological report with the oral lesions and her past medical history of HL, a diagnosis of t-AML secondary to treatment for HL was made by the oncologist. As oral lesions are one of the initial manifestations of acute leukemia, they may serve as a significant diagnostic indicator for the dental surgeons and their important role in diagnosing and treating such cases. Furthermore, this case report highlights the serious complication of t-AML subsequent to HL treatment and the important role that a general and oral health care professional may play in diagnosing and treating such cases.
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