Optimal use of procalcitonin to rule out bacteremia in patients with possible viral infections

Autor: Kaoutar Azijli, Tanca C. Minderhoud, Carlijn J. deGans, Arthur W.E. Lieveld, Prabath W.B. Nanayakkara
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American College of Emergency Physicians Open, Vol 3, Iss 3, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2688-1152
84835443
DOI: 10.1002/emp2.12621
Popis: Abstract Objective During the winter, many patients present with suspected infection that could be a viral or a bacterial (co)infection. The aim of this study is to investigate whether the optimal use of procalcitonin (PCT) is different in patients with and without proven viral infections for the purpose of excluding bacteremia. We hypothesize that when a viral infection is confirmed, this lowers the probability of bacteremia and, therefore, influences the appropriate cutoff of procalcitonin. Methods This study was conducted in the emergency department of an academic medical center in The Netherlands in the winter seasons of 2019 and 2020. Adults (>18 years) with suspected infection, in whom a blood culture and a rapid polymerase chain reaction test for influenza was performed were included. Results A total of 546 patients were included of whom 47 (8.6%) had a positive blood culture. PCT had an area under the curve of 0.85, 95% confidence interval (95% CI) 0.80–0.91, for prediction of bacteremia. In patients with a proven viral infection (N = 212) PCT
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