MLIP and Its Potential Influence on Key Oncogenic Pathways

Autor: Mahmoud N. Hamwi, Engy Elsayed, Hanan Dabash, Amani Abuawad, Noor A. Aweer, Faissal Al Zeir, Shona Pedersen, Layla Al-Mansoori, Patrick G. Burgon
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cells, Vol 13, Iss 13, p 1109 (2024)
Druh dokumentu: article
ISSN: 13131109
2073-4409
DOI: 10.3390/cells13131109
Popis: Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, and cell cycle progression, to maintain cellular homeostasis. Disruptions in this homeostasis can lead to diseases such as cancer, characterized by uncontrolled cell growth and division. This review aims to explore for the first time the unique role MLIP may play in cancer development and progression, given its interactions with the PI3K/Akt/mTOR pathway, p53, MAPK9, and FOXO transcription factors, all critical regulators of cellular homeostasis and tumor suppression. We discuss the current understanding of MLIP’s involvement in pro-survival pathways and its potential implications in cancer cells’ metabolic remodeling and dysregulated homeostasis. Additionally, we examine the potential of MLIP as a novel therapeutic target for cancer treatment. This review aims to shed light on MLIP’s potential impact on cancer biology and contribute to developing innovative therapeutic strategies.
Databáze: Directory of Open Access Journals
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