| Autor: |
Hsien-Shun Liao, Imtisal Akhtar, Christian Werner, Roman Slipets, Jorge Pereda, Jen-Hung Wang, Ellen Raun, Laura Olga Nørgaard, Frederikke Elisabet Dons, Edwin En Te Hwu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
HardwareX, Vol 12, Iss , Pp e00341- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2468-0672 |
| DOI: |
10.1016/j.ohx.2022.e00341 |
| Popis: |
High-speed atomic force microscopes (HS-AFMs) with high temporal resolution enable dynamic phenomena to be visualized at nanoscale resolution. However, HS-AFMs are more complex and costlier than conventional AFMs, and particulars of an open-source HS-AFM controller have not been published before. These high entry barriers hinder the popularization of HS-AFMs in both academic and industrial applications. In addition, HS-AFMs generally have a small imaging area that limits the fields of implementation. This study presents an open-source controller that enables a low-cost simplified AFM to achieve a maximum tip-sample velocity of 5,093 µm/s (9.3 s/frame, 512 × 512 pixels), which is nearly 100 times higher than that of the original controller. Moreover, the proposed controller doubles the imaging area to 46.3 × 46.3 µm2 compared to that of the original system. The low-cost HS-AFM can successfully assess the severity of atopic dermatitis (AD) by measuring the nanotexture of human skin corneocytes in constant height DC mode. The open-source controller-based HS-AFM system costs less than $4,000, which provides resource-limited research institutes with affordable access to high-throughput nanoscale imaging to further expand the HS-AFM research community. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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