Lower extremity muscle hypertrophy in response to resistance training in older adults: Systematic review, meta-analysis, and meta-regression of randomized controlled trials

Autor: Davi Alves de Santana, Pedro Godoi Scolfaro, Emanuele Marzetti, Cláudia Regina Cavaglieri
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Experimental Gerontology, Vol 198, Iss , Pp 112639- (2024)
Druh dokumentu: article
ISSN: 1873-6815
DOI: 10.1016/j.exger.2024.112639
Popis: Objectives: This study aimed to investigate the effects of resistance training (RT) on knee extensor muscle hypertrophy in adults 65 years and older. Methods: A systematic search was carried out in PubMed, Embase, and Scopus to review randomized controlled trials that assessed the effects of supervised RT on 1) muscle size, 2) fiber area, and 3) leg lean mass (LLM). Random-effects meta-analyses of standardized mean difference (SMD) and raw mean difference (RMD) for LLM were calculated. We performed a meta-regression to examine the interference of age, training volume, and duration on the results related to hypertrophy at muscle and fiber levels. Results: Thirty-two studies were included in the review, and 28 were meta-analyzed. The meta-analysis found a significant effect of RT on muscle size (SMD = 0.34; 95 % CI: 0.16–0.52; p
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