A genome scan for quantitative trait loci affecting the Salmonella carrier-state in the chicken

Autor: Bumstead Nat, Baret Philippe V, Velge Philippe, Vignal Alain, Plisson-Petit Florence, Pitel Frédérique, Barrow Paul A, Marly José, Tilquin Pierre, Beaumont Catherine
Jazyk: German<br />English<br />French
Rok vydání: 2005
Předmět:
Zdroj: Genetics Selection Evolution, Vol 37, Iss 6, Pp 539-561 (2005)
Druh dokumentu: article
ISSN: 1297-9686
0999-193X
DOI: 10.1186/1297-9686-37-6-539
Popis: Abstract Selection for increased resistance to Salmonella colonisation and excretion could reduce the risk of foodborne Salmonella infection. In order to identify potential loci affecting resistance, differences in resistance were identified between the N and 61 inbred lines and two QTL research performed. In an F2 cross, the animals were inoculated at one week of age with Salmonella enteritidis and cloacal swabs were carried out 4 and 5 wk post inoculation (thereafter called CSW4F2 and CSW4F2) and caecal contamination (CAECF2) was assessed 1 week later. The animals from the (N × 61) × N backcross were inoculated at six weeks of age with Salmonella typhimurium and cloacal swabs were studied from wk 1 to 4 (thereafter called CSW1BC to CSW4BC). A total of 33 F2 and 46 backcross progeny were selectively genotyped for 103 and 135 microsatellite markers respectively. The analysis used least-squares-based and non-parametric interval mapping. Two genome-wise significant QTL were observed on Chromosome 1 for CSW2BC and on Chromosome 2 for CSW4F2, and four suggestive QTL for CSW5F2 on Chromosome 2, for CSW5F2 and CSW2BC on chromosome 5 and for CAECF2 on chromosome 16. These results suggest new regions of interest and the putative role of SAL1.
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