Circulating basophils in patients with type IIb autoimmune chronic spontaneous urticaria have a lower histamine content

Autor:	Katrine Baumann, Jennifer Astrup Sørensen, Ditte G. Zhang, Misbah N. Ghazanfar, Per Stahl Skov, Anders Woetmann, Simon Francis Thomsen
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	basophil histamine release assay basophils biomarkers chronic spontaneous urticaria histamine patient stratification Dermatology RL1-803 Diseases of the genitourinary system. Urology RC870-923
Zdroj:	JEADV Clinical Practice, Vol 3, Iss 2, Pp 658-663 (2024)
Druh dokumentu:	article
ISSN:	2768-6566
DOI:	10.1002/jvc2.365
Popis:	Abstract Background Patients suffering from chronic spontaneous urticaria (CSU) are typically classified as type I or type IIb autoimmune CSU, but further patient stratification is hindered by the lack of biomarkers. Objectives We investigated whether the histamine content of individual basophils differ between patient subtypes in CSU to evaluate its potential as a biomarker. Methods A total of 101 patients diagnosed with CSU were included in the study. The histamine content per circulating basophil was derived from the basophil count in peripheral blood and levels of total cellular blood histamine. These measures, together with results from the serum‐induced basophil histamine release assay (s‐BHRA), were correlated to information on demographics, clinical characteristics, patient reported outcomes and laboratory analyses. Results The histamine content per basophil was significantly different between s‐BHRA positive and ‐negative patients (0.175 vs. 1.40 pg/cell, p
Databáze:	Directory of Open Access Journals
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