| Autor: |
Ritu Trivedi, Sulekha Adhikary, Priyanka Kothari, Naseer Ahmad, Naresh Mittapelly, Gitu Pandey, Mahendra Shukla, Sudhir Kumar, Kapil Dev, Dharmendra Choudhary, Rakesh Maurya, Jawahar Lal, Prabhat Ranjan Mishra |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Clinical Phytoscience, Vol 6, Iss 1, Pp 1-15 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2199-1197 |
| DOI: |
10.1186/s40816-020-00190-z |
| Popis: |
Abstract Background Spinach (Spinacia oleracea) is a rich source of flavonoids and therefore widely used therapeutically as an antioxidant agent in traditional medicine. The present study was undertaken to study the bone regenerating property of dried Spinacia oleracea extract (DSE) and self-emulsifying formulation of the extract (FDSE) on drill-hole model of fracture repair in rats. Methods 0.8 mm hole was drilled in the diaphyseal region of femur in adult SD rats. DSE and formulated extract (FDSE) was administered orally and fractured femur was collected after treatment regimen. Micro-CT, transcriptional analysis and measurement of calcein intensity of callus formed at the injured site was performed to study the efficacy of the extract and formulation on bone regeneration. Further, compounds from extract were assessed for in-vitro osteoblast activity. Results Micro-architecture of the regenerated bone at injured site exhibited 26% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink