Reversible splenial lesion in a patient with new-onset refractory status epilepticus (NORSE)

Autor: Akane Unno Mizutani, Akihiro Shindo, Shigeo Arikawa, Takuya Shimada, Keita Matsuura, Kaoru Ikejiri, Kei Suzuki, Hiroshi Imai, Hidekazu Tomimoto
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: eNeurologicalSci, Vol 18, Iss , Pp - (2020)
Druh dokumentu: article
ISSN: 2405-6502
DOI: 10.1016/j.ensci.2019.100220
Popis: New-onset refractory status epilepticus (NORSE) is a rare neurological emergency condition with poor prognosis. A 30-year-old male suddenly had tonic-clonic convulsions seven days after a preceding fever and diarrhea. MRI showed a reversible splenial lesion, and he developed refractory multifocal and generalized seizures in spite of anticonvulsant medication. He was diagnosed with NORSE and received a combination treatment with immunotherapy and targeted temperature management (TTM), which effectively decreased his seizures. This case suggests that even for patients with reversible splenial lesions, NORSE should be considered, and that treatment with immunotherapy and TTM may be effective. Keywords: Status epilepticus, Immunotherapy, Targeted temperature management, Acute encephalopathy, Acute encephalitis
Databáze: Directory of Open Access Journals