Multi-route antifungal administration in the management of urinary Candida glabrata bezoar

Autor: Pravin Viswambaram, Jeanie Misko, Matthew Rawlins, Sarah Clark, John Dyer, Dickon Hayne
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Urology Case Reports, Vol 33, Iss , Pp 101275- (2020)
Druh dokumentu: article
ISSN: 2214-4420
DOI: 10.1016/j.eucr.2020.101275
Popis: A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.
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