The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

Autor:	Mathieu Amand, Philipp Adams, Rafaela Schober, Gilles Iserentant, Jean-Yves Servais, Michel Moutschen, Carole Seguin-Devaux
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	anti-inflammatory agents HIV hiv reservoirs pyroptosis cytokine inflammasome inhibitors Medicine Science Biology (General) QH301-705.5
Zdroj:	eLife, Vol 12 (2023)
Druh dokumentu:	article
ISSN:	2050-084X
DOI:	10.7554/eLife.83207
Popis:	HIV-1 infection results in the activation of inflammasome that may facilitate viral spread and establishment of viral reservoirs. We evaluated the effects of the caspase-1 inhibitor VX-765 on HIV-1 infection in humanized NSG mice engrafted with human CD34+ hematopoietic stem cells. Expression of caspase-1, NLRP3, and IL-1β was increased in lymph nodes and bone marrow between day 1 and 3 after HIV-1 infection (mean fold change (FC) of 2.08, 3.23, and 6.05, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0b59b14420b948f0b3af8786ec5169fc Zobrazit plný text záznamu View record in DOAJ