| Autor: |
Txomin Lalanne, Julia Oyrer, Mark Farrant, P. Jesper Sjöström |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Frontiers in Synaptic Neuroscience, Vol 10 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1663-3563 |
| DOI: |
10.3389/fnsyn.2018.00034 |
| Popis: |
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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