The Effect of Hydroalcoholic Extract of Nectaroscordum Tripedale on Biochemical Factors in Diabetic Rats
| Autor: | S Paydar, GA Jelodar, J Mohammadi |
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| Jazyk: | perština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Armaghane Danesh Bimonthly Journal, Vol 20, Iss 5, Pp 404-415 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1728-6506 1728-6514 |
| Popis: | Background & aim: The therapeutic effects of traditional medicinal plants used in traditional medicine for many diseases have been proved. The present study was undertaken to investigate the effect of oral administration of different doses of hydroalcoholic extract of Nectaroscordum tripedale on biochemical factors. Method: Forty adult male Sprague Dawley rats were randomly divided into five groups of 8 animals as follows control group (recieved distilled water), control +50 mg/kg Nectaroscordum tripedale, diabetic control group (recieved distilled water), treatment group 1 (recieved 50mg/kg Nectaroscordum tripedale), treatment group 2 (recieved 100 mg/kg Nectaroscordum tripedales). The animals recieved Nectaroscordum tripedales extract by gavage for 21 days. Diabetes was induced by a single injection streptozotocin in rat (50 mg/kg b.w., ip). Before and 3 days after injection, 7, 14 and 21 days of treatment, the fasting glucose level and weight was measured. At the end of 21 days, blood samples collected from the heart puncture, after animals anesthetized with ether. The blood samples were analysed for lipid profile (total cholesterol, TG, HDL-c, LDL-c). Results: The results showed that the hydroalcoholic extract of Nectaroscordum tripedale could increase the average weight and decrease glucose in this period and also reduce cholesterol levels, triglyceride, and LDL-c dose dependent reduction at the end of 21 days (P |
| Databáze: | Directory of Open Access Journals |
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