Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male

Autor:	Silvia Migliaccio, Davide Francomano, Roberto Bruzziches, Emanuela A. Greco, Rachele Fornari, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	International Journal of Endocrinology, Vol 2013 (2013)
Druh dokumentu:	article
ISSN:	1687-8337 1687-8345
DOI:	10.1155/2013/182753
Popis:	Osteocalcin (OSCA) seems to act as a negative regulator of energy metabolism and insulin sensitivity. Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis. Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old). Independently from BMI, an inverse relationship between trunk fat percentage and plasma T (r2=−0.26, P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e0b4cbc932ce4420a0894838bacbd9b8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF