Alzheimer’s disease, neuroprotection, and CNS immunosenescence

Autor:	Wolfgang J Streit, QingShan eXue
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Neuroprotection neurodegeneration Alzheimer’s disease Microglial cells CNS immunosenescence impaired neuronal protection Therapeutics. Pharmacology RM1-950
Zdroj:	Frontiers in Pharmacology, Vol 3 (2012)
Druh dokumentu:	article
ISSN:	1663-9812
DOI:	10.3389/fphar.2012.00138
Popis:	This review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute towards the development of characteristic neuropathological features that characterize Alzheimer’s disease. The conceptual framework guiding our thinking is provided by the hypothesis that microglial senescence accounts for impaired neuronal protection and consequent neurodegeneration.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0b485d5b0bb44685b7fb12ca80b90d32 Zobrazit plný text záznamu View record in DOAJ