Iridium-Catalyzed asymmetric reduction of α,β-Unsaturated nitriles with water

Autor: Qinli Lu, Xianming Wang, Wanliu Wen, Ruifeng Fan, Binfeng Zhu, Bingjie Zhou, Jingchao Chen, Baomin Fan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Green Synthesis and Catalysis, Vol 5, Iss 3, Pp 175-179 (2024)
Druh dokumentu: article
ISSN: 2666-5549
DOI: 10.1016/j.gresc.2023.07.002
Popis: The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals, and the nitrile groups are versatile synthetic intermediates to other functionalized compounds. Herein, the asymmetric reduction of α, β-unsaturated nitriles with water as a hydrogen source is reported. The reaction is catalyzed by the complex of [Ir(COD)Cl]2 and (Ra, S)-Ph-Bn-SiPhox, and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.
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