Autor: |
Qinli Lu, Xianming Wang, Wanliu Wen, Ruifeng Fan, Binfeng Zhu, Bingjie Zhou, Jingchao Chen, Baomin Fan |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Green Synthesis and Catalysis, Vol 5, Iss 3, Pp 175-179 (2024) |
Druh dokumentu: |
article |
ISSN: |
2666-5549 |
DOI: |
10.1016/j.gresc.2023.07.002 |
Popis: |
The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals, and the nitrile groups are versatile synthetic intermediates to other functionalized compounds. Herein, the asymmetric reduction of α, β-unsaturated nitriles with water as a hydrogen source is reported. The reaction is catalyzed by the complex of [Ir(COD)Cl]2 and (Ra, S)-Ph-Bn-SiPhox, and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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