| Autor: |
Wellington Francisco Rodrigues, Camila Botelho Miguel, Javier Emilio Lazo-Chica, Carlos Antônio Trindade da Silva, Carlos Ueira Vieira, Juliana Trindade Clemente-Napimoga, Carlo José Freire Oliveira, Marcelo Henrique Napimoga |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Indian Society of Periodontology, Vol 23, Iss 6, Pp 511-516 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
0972-124X |
| DOI: |
10.4103/jisp.jisp_77_19 |
| Popis: |
Background: Changes in the levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) observed during periodontal disease were linked with vascular manifestations. Recent studies showed that the beta-blocker propranolol reduces the pathological parameters associated with certain molecules at sites of bone injury. Hence, in this study, we evaluated the activity of propranolol on hematological parameters and systemic concentrations of inflammatory proteins in a model of experimental periodontitis. Materials and Methods: Periodontal disease was induced in rats. After euthanasia, the number of inflammatory cells in each rat was quantified using histopathological assays. In addition, hematological parameters were quantitated using automated analysers, cytokine levels were determined using an enzyme-linked immunosorbent assay, and CRP levels were determined using a high-sensitivity immunoturbidimetric assay. Results: Low doses of propranolol suppressed the systemic production of CRP, TNF-α, and IL-6; however, the hematological parameters were not affected. Conclusions: β-adrenergic activation indirectly contributes to the pattern of systemic inflammatory molecules observed in periodontal disease. These molecules may initiate cardiovascular diseases as a consequence of periodontitis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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