Long-term Response of Helicobacter pylori Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study
| Autor: | Shiori Tanaka, Atsushi Goto, Kazumasa Yamagishi, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Hiroyasu Iso, Isao Muraki, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kiyoshi Aoyagi, Kazuhiko Arima, Kiyomi Sakata, Kozo Tanno, Manami Inoue, Norie Sawada, Shoichiro Tsugane |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Epidemiology, Vol 33, Iss 1, Pp 1-7 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0917-5040 1349-9092 |
| DOI: | 10.2188/jea.JE20200618 |
| Popis: | Background: Helicobacter pylori (H. pylori) is an established causative factor of gastric cancer. Although the expansion of insurance coverage has led to an increase in the number of patients treated for H. pylori, the population impact of eradication treatment for H. pylori has been scarcely investigated. This study aimed to clarify the long-term responses of H. pylori antibody titer after eradication treatment using large scale cross-sectional data from the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT Study). Methods: A total of 55,282 Japanese participants aged 40 to 74 years residing in 16 areas provided blood samples from 2011 through 2016. From these, treated (n = 6,276) and untreated subjects who were seropositive for H. pylori or had serological atrophy (n = 22,420) formed the study population (n = 28,696). Seropositivity was defined as an anti-H. pylori IgG titer of ≥10 U/mL. Antibody level was compared among subjects according to self-reported treatment history as untreated, and treated for less than 1 year ( |
| Databáze: | Directory of Open Access Journals |
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