Timing of renal replacement therapy and long-term risk of chronic kidney disease and death in intensive care patients with acute kidney injury

Autor: Søren Christiansen, Steffen Christensen, Lars Pedersen, Henrik Gammelager, J. Bradley Layton, M. Alan Brookhart, Christian Fynbo Christiansen
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Critical Care, Vol 21, Iss 1, Pp 1-9 (2017)
Druh dokumentu: article
ISSN: 1364-8535
DOI: 10.1186/s13054-017-1903-y
Popis: Abstract Background The optimal time to initiate renal replacement therapy (RRT) in intensive care unit (ICU) patients with acute kidney injury (AKI) is unclear. We examined the impact of early RRT on long-term mortality, risk of chronic kidney disease (CKD), and end-stage renal disease (ESRD). Methods This cohort study included all adult patients treated with continuous RRT in the ICU at Aarhus University Hospital, Skejby, Denmark (2005–2015). Data were obtained from a clinical information system and population-based registries. Early treatment was defined as RRT initiation at AKI stage 2 or below, and late treatment was defined as RRT initiation at AKI stage 3. Inverse probability of treatment (IPT) weights were computed from propensity scores. The IPT-weighted cumulative risk of CKD (estimated glomerular filtration rate
Databáze: Directory of Open Access Journals
Externí odkaz: