An extremely rare case of nivolumab‐associated macroscopic duodenitis with spontaneous regression

Autor: Takatora Akizawa, Takeshi Saraya, Hiroki Takakura, Masachika Fujiwara, Haruyuki Ishii, Hajime Takizawa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Respirology Case Reports, Vol 8, Iss 5, Pp n/a-n/a (2020)
Druh dokumentu: article
ISSN: 2051-3380
DOI: 10.1002/rcr2.582
Popis: Abstract An 82‐year‐old man was presented to our hospital due to epigastric and right hypochondrial pain 17 weeks after the initiation of intravenous treatment with nivolumab for recurrent lung adenocarcinoma as multiple lung and sternal metastases. Urgent gastroscopy revealed macroscopic duodenitis such as severe erythema, oedema, black‐coloured erosions, and ulcers located throughout the second portion of the duodenum, which was confirmed by abdominal computed tomography as circumferential thickening of the duodenal wall. Those lesions were pathologically considered as non‐specific inflammation and spontaneously disappeared within a month, suggesting nivolumab‐induced immune‐related adverse events.
Databáze: Directory of Open Access Journals