Voltage Sensors Embedded in G Protein-Coupled Receptors

Autor:	Merav Tauber, Yair Ben-Chaim
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	G protein coupled receptors muscarinic receptor voltage dependence voltage sensor Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 25, Iss 10, p 5295 (2024)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms25105295
Popis:	Some signaling processes mediated by G protein-coupled receptors (GPCRs) are modulated by membrane potential. In recent years, increasing evidence that GPCRs are intrinsically voltage-dependent has accumulated. A recent publication challenged the view that voltage sensors are embedded in muscarinic receptors. Herein, we briefly discuss the evidence that supports the notion that GPCRs themselves are voltage-sensitive proteins and an alternative mechanism that suggests that voltage-gated sodium channels are the voltage-sensing molecules involved in such processes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0b1669b0f2a948d69a4a90420f7136b8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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