Differential expression of antiviral and immune-related genes in individuals with COVID-19 asymptomatic or with mild symptoms

Autor: Malena Gajate-Arenas, Omar García-Pérez, Javier Chao-Pellicer, Angélica Domínguez-De-Barros, Roberto Dorta-Guerra, Jacob Lorenzo-Morales, Elizabeth Córdoba-Lanus
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Druh dokumentu: article
ISSN: 2235-2988
DOI: 10.3389/fcimb.2023.1173213
Popis: COVID-19 is characterized by a wide range of symptoms where the genetic background plays a key role in SARS-CoV-2 infection. In this study, the relative expression of IRF9, CCL5, IFI6, TGFB1, IL1B, OAS1, and TFRC genes (related to immunity and antiviral activity) was analyzed in upper airway samples from 127 individuals (97 COVID-19 positive and 30 controls) by using a two-step RT-PCR. All genes excepting IL1B (p=0.878) showed a significantly higher expression (p
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