| Autor: |
Seyed Gholamhossein Mansouri, Hassan Zali-Boeini, Kamiar Zomorodian, Bahman Khalvati, Razie Helali Pargali, Ali Dehshahri, Hadi Amiri Rudbari, Mehdi Sahihi, Zahra Chavoshpour |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 1271-1282 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2017.10.009 |
| Popis: |
A series of novel naphtho[1,2-e][1,3]oxazines bearing arylsulfonamide moiety have been synthesized via a one-pot approach and in a green reaction medium. These new naphtho[1,2-e][1,3]oxazine derivatives have been characterized by their 1H NMR, 13C NMR and the X-ray single crystallography method for compound 7a. All the newly synthesized compounds were examined for their in vitro anticancer activity against breast (MCF-7), colon (HCT116), and B-CLL (Waco3-CD5) cancers. Some of these compounds such as 7j and 7l showed remarkable activities against MCF-7 (breast) and HCT116 (colon) cancers with comparable IC50 (The half maximal inhibitory concentration) values as that of known drugs such as 5-fluorouracil (5-FU). In vitro antimicrobial activities of all compounds were also evaluated against five human pathogenic fungi strains and two bacteria (one gram positive and one gram negative). The best MICs (Minimum Inhibitory Concentrations) were found against the C. albicans. Keywords: Anticancer, Naphthoxazine, Sulfonamide, Synthesis, Antifungal |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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