Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.
| Autor: | Piotr Laudański, Adam Lemancewicz, Paweł Kuć, Małgorzata Krętowska, Tadeusz Laudański |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 48, Iss 3, Pp 366-370 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0239-8508 1897-5631 |
| DOI: | 10.5603/4212 |
| Popis: | Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I - pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II - threatened preterm labour patients between 24-34 weeks of gestation; III - preterm vaginal delivery patients; IV - healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|