Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO).

Autor: Jolene Ramsey, Brenley McIntosh, Daniel Renfro, Suzanne A Aleksander, Sandra LaBonte, Curtis Ross, Adrienne E Zweifel, Nathan Liles, Shabnam Farrar, Jason J Gill, Ivan Erill, Sarah Ades, Tanya Z Berardini, Jennifer A Bennett, Siobhan Brady, Robert Britton, Seth Carbon, Steven M Caruso, Dave Clements, Ritu Dalia, Meredith Defelice, Erin L Doyle, Iddo Friedberg, Susan M R Gurney, Lee Hughes, Allison Johnson, Jason M Kowalski, Donghui Li, Ruth C Lovering, Tamara L Mans, Fiona McCarthy, Sean D Moore, Rebecca Murphy, Timothy D Paustian, Sarah Perdue, Celeste N Peterson, Birgit M Prüß, Margaret S Saha, Robert R Sheehy, John T Tansey, Louise Temple, Alexander William Thorman, Saul Trevino, Amy Cheng Vollmer, Virginia Walbot, Joanne Willey, Deborah A Siegele, James C Hu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: PLoS Computational Biology, Vol 17, Iss 10, p e1009463 (2021)
Druh dokumentu: article
ISSN: 1553-734X
1553-7358
DOI: 10.1371/journal.pcbi.1009463
Popis: Experimental data about gene functions curated from the primary literature have enormous value for research scientists in understanding biology. Using the Gene Ontology (GO), manual curation by experts has provided an important resource for studying gene function, especially within model organisms. Unprecedented expansion of the scientific literature and validation of the predicted proteins have increased both data value and the challenges of keeping pace. Capturing literature-based functional annotations is limited by the ability of biocurators to handle the massive and rapidly growing scientific literature. Within the community-oriented wiki framework for GO annotation called the Gene Ontology Normal Usage Tracking System (GONUTS), we describe an approach to expand biocuration through crowdsourcing with undergraduates. This multiplies the number of high-quality annotations in international databases, enriches our coverage of the literature on normal gene function, and pushes the field in new directions. From an intercollegiate competition judged by experienced biocurators, Community Assessment of Community Annotation with Ontologies (CACAO), we have contributed nearly 5,000 literature-based annotations. Many of those annotations are to organisms not currently well-represented within GO. Over a 10-year history, our community contributors have spurred changes to the ontology not traditionally covered by professional biocurators. The CACAO principle of relying on community members to participate in and shape the future of biocuration in GO is a powerful and scalable model used to promote the scientific enterprise. It also provides undergraduate students with a unique and enriching introduction to critical reading of primary literature and acquisition of marketable skills.
Databáze: Directory of Open Access Journals
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