Identification of a Rare EGFR T790I Mutation in Lung Adenocarcinoma Sensitive to Osimertinib

Autor: Yu Wang, Songtao Liu, Alei Feng, Huan Luo, Jinwei Hu, Kai Wang, Wei Dong
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Oncology, Vol 11 (2021)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2021.727312
Popis: Estimated glomerular filtration rate (EGFR)-sensitive mutations are extremely important for targeted treatment strategies in lung cancer. Osimertinib can effectively inhibit the activity of EGFR-sensitive mutations, including the T790M mutation. However, the efficiency of osimertinib for rare mutation types of T790 is unclear. Here, we report the case of a Chinese patient with lung adenocarcinoma (LADC) harboring a T790I mutation who achieved significant benefits from osimertinib treatment.
Databáze: Directory of Open Access Journals