Studies on the Biological Effects of Ozone: 10. Release of Factors from Ozonated Human Platelets

Autor:	G. Valacchi, Velio Bocci
Jazyk:	angličtina
Rok vydání:	1999
Předmět:	ozone platelets aggregation growth factors inteleukin-8. Pathology RB1-214
Zdroj:	Mediators of Inflammation, Vol 8, Iss 4-5, Pp 205-209 (1999)
Druh dokumentu:	article
ISSN:	0962-9351 1466-1861
DOI:	10.1080/09629359990360
Popis:	In a previous work we have shown that heparin, in the presence of ozone (O3), promotes a dose-dependent platelet aggregation, while after Ca2+ chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet components. We have here shown that indeed significantly higher amount of platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1) and interleukin-8(IL-8) are released in a dose-dependent manner after ozonation of heparinised platelet-rich plasma samples. These findings may explain the enhanced healing of torpid ulcers in patients with chronic limbischemia treated with O3 autohaemoteraphy (O3-AHT).
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0ad178ec58674f45ae6ab653db21143a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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