Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful?

Autor: Parvaz Madadi, Johanna Sistonen, Gregory Silverman, Rebecca Gladdy, Colin J Ross, Bruce C Carleton, Jose C Carvalho, Michael R Hayden, Gideon Koren
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Pain Research and Management, Vol 18, Iss 3, Pp 133-136 (2013)
Druh dokumentu: article
ISSN: 1203-6765
DOI: 10.1155/2013/518012
Popis: BACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is presented. The usefulness of genotyping in the context of these cases is discussed.
Databáze: Directory of Open Access Journals