Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan

Autor: Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Masaru Sakurai, Masao Ishizaki, Teruhiko Kido
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Toxics, Vol 6, Iss 2, p 23 (2018)
Druh dokumentu: article
ISSN: 2305-6304
DOI: 10.3390/toxics6020023
Popis: After 26 years, we followed up 7348 participants in a 1979–1984 health screening survey in the Jinzu River basin, the heaviest cadmium-polluted area in Japan. We assessed the associations of cadmium exposure levels and mortality from cancer and renal damage, indicated by records of proteinuria and glucosuria in the original survey. Mortality risks (hazard ratios) were analyzed using the Cox proportional hazards model, stratified by sex, after adjusting for age, smoking status, and hypertension, as indicated in the original survey records. In men, the adjusted hazard ratio for mortality from lung cancer was significantly lower in individuals residing in an area of historically high cadmium exposure and in subjects with a historical record of proteinuria, glucosuria, and glucoproteinuria. The risk of mortality from prostate cancer was borderline higher in cadmium-exposed men. In women, historical cadmium exposure was not associated with an increased risk of mortality from malignant neoplasms, but the adjusted hazard ratios for death from total malignant neoplasms or from renal and uterine cancers were significantly higher in exposed subjects with a historical record of proteinuria, glucosuria, and glucoproteinuria. These findings suggest that women residing in cadmium-polluted areas who exhibit markers of renal damage may be at risk of dying of cancer.
Databáze: Directory of Open Access Journals