Transcutaneous cervical vagal nerve stimulation reduces sympathetic responses to stress in posttraumatic stress disorder: A double-blind, randomized, sham controlled trial
| Autor: | Nil Z. Gurel, Matthew T. Wittbrodt, Hewon Jung, Md. Mobashir H. Shandhi, Emily G. Driggers, Stacy L. Ladd, Minxuan Huang, Yi-An Ko, Lucy Shallenberger, Joy Beckwith, Jonathon A. Nye, Bradley D. Pearce, Viola Vaccarino, Amit J. Shah, Omer T. Inan, J. Douglas Bremner |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Posttraumatic stress disorder
Wearable bioelectronic medicine Vagus nerve stimulation Transcutaneous cervical stimulation Stress Electroceuticals Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495 |
| Zdroj: | Neurobiology of Stress, Vol 13, Iss , Pp 100264- (2020) |
| Druh dokumentu: | article |
| ISSN: | 2352-2895 |
| DOI: | 10.1016/j.ynstr.2020.100264 |
| Popis: | Objective: Exacerbated autonomic responses to acute stress are prevalent in posttraumatic stress disorder (PTSD). The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on autonomic responses to acute stress in patients with PTSD. The authors hypothesized tcVNS would reduce the sympathetic response to stress compared to a sham device. Methods: Using a randomized double-blind approach, we studied the effects of tcVNS on physiological responses to stress in patients with PTSD (n = 25) using noninvasive sensing modalities. Participants received either sham (n = 12) or active tcVNS (n = 13) after exposure to acute personalized traumatic script stress and mental stress (public speech, mental arithmetic) over a three-day protocol. Physiological parameters related to sympathetic responses to stress were investigated. Results: Relative to sham, tcVNS paired to traumatic script stress decreased sympathetic function as measured by: decreased heart rate (adjusted β = −5.7%; 95% CI: ±3.6%, effect size d = 0.43, p |
| Databáze: | Directory of Open Access Journals |
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