| Autor: |
Tímea Szabó, Róbert Kormány, András Dancsó, Balázs Volk, Mátyás Milen |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
SynOpen, Vol 03, Iss 04, Pp 148-156 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2509-9396 |
| DOI: |
10.1055/s-0039-1690336 |
| Popis: |
Abstract Pimprinols A, B, and C are bacterial 5-(3-indolyl)oxazole alkaloids that have been isolated from Streptomyces sp. Lv3–13. In this paper, we report a new synthesis of pimprinol A and the first total synthesis of pimprinol B and pimprinol C. In addition, antipodes of the naturally occurring pimprinols A and C, as well as the racemates of these two alkaloids were also prepared. In the pivotal step, the 1,3-oxazole ring was constructed by a Nicolaou’s modified Robinson–Gabriel cyclization. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
