Stereoselective Biginelli-like reaction catalyzed by a chiral phosphoric acid bearing two hydroxy groups

Autor:	Xiaoyun Hu, Jianxin Guo, Cui Wang, Rui Zhang, Victor Borovkov
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	asymmetric biginelli-like reaction chiral 1 1 4 4-tetraphenylbutanetetraol chiral phosphoric acid Science Organic chemistry QD241-441
Zdroj:	Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1875-1880 (2020)
Druh dokumentu:	article
ISSN:	1860-5397 81573588
DOI:	10.3762/bjoc.16.155
Popis:	To develop new efficient stereoselective catalysts for Biginelli-like reactions, a chiral phosphoric acid bearing two hydroxy groups derived from ʟ-tartaric acid was successfully synthesized via highly regioselective transformations of enantiopure 1,1,4,4-tetraphenylbutanetetraol. The obtained catalyst effectively catalyzed Biginelli-like reactions with moderate to good enantioselectivities. Control experiments indicated that the presence of the two hydroxy groups were indispensable for achieving a high enantioselectivity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0a9c6d27e3124d0b81573588e2ac36f6 Zobrazit plný text záznamu View record in DOAJ