The enigmatic nature of the triggering receptor expressed in myeloid cells -1 (TLT- 1)

Autor: Siobhan Branfield, A. Valance Washington
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Platelets, Vol 32, Iss 6, Pp 753-760 (2021)
Druh dokumentu: article
ISSN: 0953-7104
1369-1635
09537104
DOI: 10.1080/09537104.2021.1881948
Popis: Receptors are important pharmacological targets on cells. The Triggering Receptor Expressed on Myeloid Cells (TREM) – Like Transcript – 1 is an abundant, yet little understood, platelet receptor. It is a single Ig domain containing receptor isolated in the α-granules of resting platelets and brought to the platelet surface upon activation. On platelets, the integrin αIIbβ3 is the major receptor having roughly 80,000 copies. αIIbβ3 is a heterodimeric multidomain structure that mediates platelet aggregation through its interaction with the plasma protein fibrinogen. Anti-platelet drugs have successfully targeted αIIbβ3 to control thrombosis. Like αIIbβ3, TLT-1 also binds fibrinogen, making its role in platelet function somewhat obscure. In this review, we highlight the known structural features of TLT-1 and present the challenges of understanding TLT-1 function. In our analysis of the dynamics of the platelet surface after activation we propose a model in which TLT-1 supports αIIbβ3 function as a mechanoreceptor that may direct platelets toward immune function.
Databáze: Directory of Open Access Journals
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