Pituitary dysfunction in traumatic brain injury: Is evaluation in the acute phase worthwhile?

Autor: Pradip P Dalwadi, Nikhil M Bhagwat, Parimal S Tayde, Ameya S Joshi, Premlata K Varthakavi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Indian Journal of Endocrinology and Metabolism, Vol 21, Iss 1, Pp 80-84 (2017)
Druh dokumentu: article
ISSN: 2230-8210
DOI: 10.4103/2230-8210.196018
Popis: Introduction: Traumatic brain injury (TBI) is an under-recognized cause of hypopituitarism. According to recent data, it could be more frequent than previously known. However, there is a scarcity of data in Indian population. Aims: The main aim of the study was to determine the prevalence of pituitary hormone deficiencies in the acute phase of TBI. The secondary objectives were to correlate the severity of trauma with basal hormone levels and to determine whether initial hormone deficiencies predict mortality. Subjects and Methods: Forty-nine TBI patients (41 men and 8 women) were included in this study. Pituitary functions were evaluated within 24 h of admission. Results: Gonadotropin deficiency was found in 65.3% patient while 46.9% had low insulin-like growth factor-1, 12.24% had cortisol level
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