Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O2 Control and the Natural Electron Donor

Autor: Dr. Célia M. Silveira, Dr. Patrícia R. Rodrigues, Dr. Wissam Ghach, Dr. Sofia A. Pereira, Dr. Francisco Esteves, Dr. Michel Kranendonk, Dr. Mathieu Etienne, Prof. Dr. M. Gabriela Almeida
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: ChemElectroChem, Vol 8, Iss 3, Pp 430-430 (2021)
Druh dokumentu: article
ISSN: 2196-0216
20200161
DOI: 10.1002/celc.202001615
Popis: Abstract Invited for this month's cover picture is the Group of Biomarkers and Biosensors – GB2 (https://gb29.webnode.pt) at Universidade NOVA de Lisboa (Portugal) and CiiEM (Portugal). The cover picture shows the electrochemical response of the human monooxygenase enzyme, cytochrome P450 1A2 (CYP1A2), in the presence of its natural electron donor partner, cytochrome P450 oxidoreductase (CPR), highlighting the role of the interaction with the latter in the stabilization of CYP1A2 and attaining the electrochemically driven activity towards O2. The picture also emphasizes the protein entrapment matrix, a biocompatible sol‐gel film, which proved to be crucial for the achievement of interfacial electron transfer. Read the full text of the Article at 10.1002/celc.202001255.
Databáze: Directory of Open Access Journals
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