| Autor: |
Jon Dorling, Lehana Thabane, Souvik Mitra, Anup C Katheria, Walid El-Naggar, Dany E Weisz, Amish Jain, Michael Castaldo, Patrick J McNamara, Abbas Hyderi, Kumar Kumaran, Tara Hatfield, Audrey Hebert, Jenny Koo, Tim Disher, Santokh Dhillon, Ziad Alhassen, Marjorie Makoni, Fabiana Bacchini, Austin Cameron |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 14, Iss 7 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2024-087998 |
| Popis: |
Introduction Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in extremely preterm infants and is associated with poor clinical outcomes. Uncertainty exists on whether early pharmacotherapeutic treatment of a clinically symptomatic and echocardiography-confirmed haemodynamically significant PDA in extremely preterm infants improves outcomes. Given the wide variation in the approach to PDA treatment in this gestational age (GA) group, a randomised trial design is essential to address the question. Before embarking on a large RCT in this vulnerable population, it is important to establish the feasibility of such a trial.Methods and analysis Design: a multi-centre, open-labelled, parallel-designed pilot randomised controlled trial.Participants: preterm infants born |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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