Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy

Autor:	J. Angel Navarro-Becerra, Mark A. Borden
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	targeted microbubbles ultrasound imaging probes ultrasound-targeted delivery therapy immunotherapy Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 15, Iss 6, p 1625 (2023)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics15061625
Popis:	Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through bioconjugation of a ligand, drug and/or cell. Since their inception a few decades ago, several targeted microbubble (tMB) formulations have been developed as ultrasound imaging probes and ultrasound-responsive carriers to promote the local delivery and uptake of a wide variety of drugs, genes, and cells in different therapeutic applications. The aim of this review is to summarize the state-of-the-art of current tMB formulations and their ultrasound-targeted delivery applications. We provide an overview of different carriers used to increase drug loading capacity and different targeting strategies that can be used to enhance local delivery, potentiate therapeutic efficacy, and minimize side effects. Additionally, future directions are proposed to improve the tMB performance in diagnostic and therapeutic applications.
Databáze:	Directory of Open Access Journals
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