Clinical characteristics and prognostic analysis of CDKN2A/2B gene in pediatric acute lymphoblastic leukemia: a retrospective case-control study

Autor:	Shi-Mei Huang, Hui-Qin Chen, Li-Ting Liu, Ya-Ting Zhang, Jian Wang, Dun-Hua Zhou, Jian-Pei Fang, Lu-Hong Xu
Jazyk:	angličtina
Rok vydání:	2025
Předmět:	Pediatric ALL CDKN2A/2B gene deletion clinical characteristics prognosis analysis Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Hematology, Vol 30, Iss 1 (2025)
Druh dokumentu:	article
ISSN:	16078454 1607-8454
DOI:	10.1080/16078454.2024.2439606
Popis:	In this retrospective case-control study involving 424 pediatric patients diagnosed with Pediatric Acute Lymphoblastic Leukemia (ALL), the investigation focused on analyzing the clinical characteristics and prognosis associated with the Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) gene. Treatment and evaluation followed the South China Children's Leukemia Group-ALL-2016 protocol (SCCLG-ALL-2016). Among the cohort, 92 patients (21.7%) exhibited CDKN2A/2B gene deletions, with 11.1% homozygous and 10.6% heterozygous deletions. Notably, ALL patients that do have CDKN2A/2B gene deletions tended to present at an older age (P = 0.001), demonstrate hepatosplenomegaly on palpation (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0a5e1ab84511483fb4af2fe5a4a067c6 Zobrazit plný text záznamu View record in DOAJ