Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
| Autor: | Amy Rebecca Bentley, Ayo P. Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, CongQing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A. Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N. Rotimi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | International Journal of Nephrology, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2090-214X 2090-2158 |
| DOI: | 10.1155/2012/748984 |
| Popis: | Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n=1100), West Africans (WA, n=1497), and African Americans (AA, n=1539). There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β=0.13, P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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