Carboxylesterases in lipid metabolism: from mouse to human

Autor: Jihong Lian, Randal Nelson, Richard Lehner
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Protein & Cell, Vol 9, Iss 2, Pp 178-195 (2017)
Druh dokumentu: article
ISSN: 1674-800X
1674-8018
DOI: 10.1007/s13238-017-0437-z
Popis: ABSTRACT Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through (over)expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, differences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human carboxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.
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