Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study

Autor: Yoko Kubosawa, Tomohisa Sujino, Kentaro Miyamoto, Atsuto Kayashima, Daisuke Minezaki, Kohei Morioka, Kentaro Iwata, Kurato Miyazaki, Teppei Masunaga, Mari Mizutani, Teppei Akimoto, Yusaku Takatori, Noriko Matsuura, Atsushi Nakayama, Kaoru Takabayashi, Nobuhiro Nakamoto, Akira Honda, Motohiko Kato, Naohisa Yahagi, Takanori Kanai
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-69820-7
Popis: Abstract The incidence of duodenal tumors (DTs) is increasing. However, the mechanisms underlying its development remain unclear. Environmental factors, including the microbiome and bile acids (BAs), are believed to influence tumor development. Therefore, we conducted a single-center, prospective, observational study to investigate the potential differences between patients with DTs and healthy controls (HCs) based on these factors. In addition, the BAs in the duodenal fluid were measured using liquid chromatography-tandem mass spectrometry. We recruited 41 patients and performed 16S rRNA-seq. There was no difference in the observed ASVs or PCoA plot of Bray–Curtis dissimilarity between the DTs and HCs. The lithocholic acid concentration was significantly lower in the DT group than in the control group. The ratio of CDCA to LCA was significantly higher in patients with DTs. No significant differences in microbiota were observed between DTs and HCs. In patients with DTs, the lithocholic acid concentration in duodenal was significantly lower than in HCs.
Databáze: Directory of Open Access Journals
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