Synthesis of the 4-desmethoxy analogue of RU79115

Autor: MICHEL KLICH, ANNE-MARIE PERIERS, NICOLE TESSOT, BRANISLAV MUSICKI
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Journal of the Serbian Chemical Society, Vol 69, Iss 11, Pp 855-859 (2004)
Druh dokumentu: article
ISSN: 0352-5139
Popis: The synthesis, and biological activity in vitro of the 4-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.
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