Association between serum uric acid and kidney disease with pediatric focus

Autor:	Myung Hyun Cho
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	child hyperuricemia renal insufficiency chronic uric acid Internal medicine RC31-1245 Pediatrics RJ1-570
Zdroj:	Childhood Kidney Diseases, Vol 28, Iss 3, Pp 106-111 (2024)
Druh dokumentu:	article
ISSN:	2384-0242 2384-0250
DOI:	10.3339/ckd.24.016
Popis:	Hyperuricemia is a global medical issue. Kidney disease and hyperuricemia are clearly related. Whether uric acid is a disease bystander or a therapeutic target in chronic kidney disease (CKD) remains controversial. Uric acid is involved in various mechanisms that worsen kidney function, and many epidemiological and animal studies have shown an association between hyperuricemia and kidney deterioration. However, several confounding variables limit this interpretation of the relationship. Two recent large well-designed studies failed to show that allopurinol, a uric acid-lowering agent, slows the decline in glomerular filtration rate. Nevertheless, this conclusion remains premature. The role of uric acid-lowering agents in delaying disease progression in patients with early-stage CKD, such as pediatric patients, requires further study.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0a246855675c46c6a384786aba6958aa Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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