Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder

Autor:	Tadashi Kanamori, Masahiro Suzuki, Yoshiyuki Kaneko, Kouju Yamada, Hideyuki Kubo, Makoto Uchiyama
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Bipolar disorder Hypothyroidism Symptomatic Valproate Psychiatry RC435-571
Zdroj:	Annals of General Psychiatry, Vol 19, Iss 1, Pp 1-3 (2020)
Druh dokumentu:	article
ISSN:	1744-859X
DOI:	10.1186/s12991-020-00299-y
Popis:	Abstract Background Valproate-induced hypothyroidism is a rare condition and has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism. Case presentation A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function. Conclusions Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0a1cc6516d1b4c25b6c827d23f1ea91c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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